Arrhythmias & electrophysiology
Burden of mood symptoms and disorders in implantable cardioverter defibrillator patients: a systematic review and meta-analysis of 39 954 patients
Authors' conclusion
Depression and anxiety are highly prevalent in ICD patients, especially in those who experience shocks. Of particular concern is the prevalence of PTSD following ICD implantation.
Study context
- Population
- Patients with an ICD109 articles
- Participants
- 39,954 patients
- Outcome
- Prevalence of mood disorders (anxiety, depression, PTSD) and symptom severity, pre- and post-ICD insertion
Methodological detailsrandom-effects, Medline, PsycINFO, PubMed and Embase searched from inception to 31 August 2022
- Random-effects
- Medline, PsycINFO, PubMed and Embase searched from inception to 31 August 2022
Pooled result
As reported in the abstract
all timepoints following insertion
Clinically relevant anxiety
22.58%
95%CI 18.26–26.91%
Depression
15.42%
95%CI 11.90–18.94%
Post-traumatic stress disorder (PTSD)
12.43%
95%CI 6.90–17.96%
Further pooled results
| Outcome | OR (95% CI) | |
|---|---|---|
| Clinically relevant anxiety and depression, shocks vs no shocksShocksvs No shocksAnxiety | 3.92 (1.67–9.19) | |
| Clinically relevant anxiety and depression, shocks vs no shocksShocksvs No shocksDepression | 1.87 (1.34–2.59) | |
| 0.10.31310Odds ratio (log scale) |
| Outcome | Hedges' g (95% CI) | |
|---|---|---|
| Anxiety symptoms post-insertion, femalesvs malesHigher anxiety symptoms in females | 0.39 (0.15–0.62) | |
| −0.500.51Difference (linear scale) |
Change in depression and anxiety symptoms over time post-insertion
| Hedges' g (95% CI) | ||
|---|---|---|
| Depression symptomsDecreased in the first 5 months post-insertion | 0.13 (0.03–0.23) | |
| Anxiety symptomsDecreased after 6 months | 0.07 (0–0.14) | |
| −0.100.10.20.3Difference (linear scale) |
Rates by indication (primary vs secondary)
- Rates did not vary relative to indication group
Original publication
Burden of mood symptoms and disorders in implantable cardioverter defibrillator patients: a systematic review and meta-analysis of 39 954 patients. Europace. Published 13 June 2023. doi:10.
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