Burden of cardiovascular risk factors and cardiovascular disease in childhood cancer survivors: data from the German CVSS-study
Authors' conclusion
This large CCS screening examination revealed consistently in comparison to three population samples a considerably increased risk for premature CVD.
Study context
- Population
- German long-term childhood cancer survivors aged 23–48 years951 compared
- Participants
- 1,002 survivors
- Exposure
- Childhood cancer survivors vs general population
- Outcome
- Prevalence of CV risk factors and CVD
Methodological detailsprospective systematic standardized screening, compared with population-based cohorts
- Prospective systematic standardized screening
- Compared with population-based cohorts
Main finding
As reported in the abstract
- Arterial hypertension, RR
- 1.38 (1.21-1.57) (95% CI)
- Dyslipidaemia, RR
- 1.26 (1.12-1.42) (95% CI)
- Hypertension, rate advancement period
- 5.75 (3.5-8.0) (95% CI)
- Dyslipidaemia, rate advancement period
- 8.16 (4.4-11.9) (95% CI)
- Overt cardiovascular disease (CVD) prevalence in childhood cancer survivors (CCS)
- 4.5% (3.0-6.6%) (95% CI)
- Overt CVD, RR
- 1.89 (1.34-2.66) (95% CI)
- Overt CVD, rate advancement period
- 7.9 (4.1-11.7) (95% CI)
Observational data: associations, not effects.
Original publication
Burden of cardiovascular risk factors and cardiovascular disease in childhood cancer survivors: data from the German CVSS-study. Eur Heart J. Published 9 March 2018. doi:10.
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