Heart failure & cardiomyopathies
Calcium Channel Blocker Use and Outcomes in Patients with Heart Failure and Mildly Reduced and Preserved Ejection Fraction
Authors' conclusion
Although this is an observational analysis of non-randomized treatment, there was no suggestion that CCBs were associated with worse HF outcomes. Indeed, CCB use was associated with a lower incidence of pump failure death.
Study context
- Population
- Patients with HFmrEF/HFpEF from four large trials
- Participants
- 16,954 patients4 trials
- Comparison
- CCB use vs no CCB
- CCBn = 5,874
- Outcome
- Death, HF hospitalization, pump failure death, stroke
Methodological detailsobservational analysis of non-randomized treatment
- Observational analysis of non-randomized treatment
Pooled result
As reported in the abstract
CCB vs No CCBHazard ratio (95% CI)
Pump failure death
0.76(0.60–0.96)
Stroke
1.26(1.06–1.50)
Further pooled results
Outcomes by CCB subtype (dihydropyridine vs non-dihydropyridine)
- Pattern of outcomes broadly similar for both subtypes
Original publication
Calcium Channel Blocker Use and Outcomes in Patients with Heart Failure and Mildly Reduced and Preserved Ejection Fraction. Eur J Heart Fail. Published 5 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →