Calcium Modification After Orbital Atherectomy and Balloon Angioplasty in Severely Calcified Lesions: The ECLIPSE Optical Coherence Tomography (OCT) Substudy
Authors' conclusion
Despite greater calcium modification after OA, the acute MSA and 1-year target-vessel failure rates were not different between OA and BA.
Study context
- Population
- Patients with severely calcified coronary lesions undergoing drug-eluting stent implantation286 vs 292 lesions with OCT
- Participants
- 276 vs 279
- Comparison
- Orbital atherectomy vs balloon angioplasty before drug-eluting stent implantation
- Orbital atherectomy (OA)n = 276
- Balloon angioplasty (BA)n = 279reference
- Primary endpoint
- MSA at the site of maximal calcification (OCT)
- Follow-up
- Postprocedural
Methodological detailsOCT substudy, prospective, multicentre
- OCT substudy
- Prospective
- Multicentre
Primary result
As reported in the abstract
MSA at site of maximal calcification
P = 0.08
Further findings
Target-vessel failure (OCT substudy) · 1 year · not different
P = 0.61
- Minimal stent area (MSA) across the entire stent
- P = 0.10
- MSA across the entire stent: median [IQR] 5.86 [4.60-7.38] vs 5.57 [4.50-6.97] mm²; similar results
Calcium modification (number, total length and maximal depth of calcium fractures)
- Greater calcium modification with OA vs BA, especially in lesions with thicker calcium
Original publication
Calcium Modification After Orbital Atherectomy and Balloon Angioplasty in Severely Calcified Lesions: The ECLIPSE OCT Substudy. Circ Cardiovasc Interv. Published 3 December 2025. doi:10.
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