Arrhythmias & electrophysiology
CAMERA-MRI score to predict left ventricular ejection fraction normalization post-ablation for primary atrial fibrillation-mediated cardiomyopathy: A pooled analysis of two randomized clinical trials
Authors' conclusion
Absence of late gadolinium enhancement, normal LV volumes, and absence of an alternative etiology identified that the AF-induced cardiomyopathy phenotype is most likely to achieve LVEF normalization following catheter ablation.
Study context
- Population
- Patients with atrial fibrillation (AF)-mediated cardiomyopathy who underwent catheter ablation, with baseline and serial cardiac magnetic resonancepatients included, 70 (63.7%) achieved left ventricular ejection fraction (LVEF) normalization
- Participants
- 113 patients
- Comparison
- Predictors of LVEF normalization following catheter ablation
Methodological detailsinternally validated through bootstrap resampling (200 iterations) and 5-fold cross-validation, univariable and multivariable logistic regression
- Internally validated through bootstrap resampling (200 iterations) and 5-fold cross-validation
- Univariable and multivariable logistic regression
Pooled result
As reported in the abstract
Independent predictors of LVEF normalization (multivariable analysis)
Odds ratio (95% CI)P value
Normal indexed LV end-diastolic volume
3.20(1.20–8.56)
P = 0.021Absence of alternate etiology
4.31(1.14–16.39)
P = 0.023Absence of late gadolinium enhancement
2.53(1.01–6.39)
P = 0.049Further pooled results
Score model performance
- Area under the curve
- 0.788 (95% CI, 0.703-0.873)
Normalization likelihood by score
- Score 0/3
- 12%
- Score 1/3
- 38%
- Score 2/3
- 67%
- Score 3/3
- 88%
Original publication
CAMERA-MRI score to predict left ventricular ejection fraction normalization post-ablation for primary atrial fibrillation-mediated cardiomyopathy: A pooled analysis of two randomized clinical trials. Heart Rhythm. Published 14 July 2026. doi:10.
Summarised from the published abstract; every number is checked against it