Arrhythmias & electrophysiology
Prognostic value of electrocardiogram (ECG)-derived f-wave indices from implantable loop recorder: Analysis from the LOOP study
Authors' conclusion
In screening-detected AF, indices of a more organized fibrillatory process (low AFR/ExpDec) and advanced structural abnormalities (low FWA) were associated with increased mortality and heart failure events. F-wave analysis identifies high-risk patients in early AF, potentially enabling targeted interventions.
Study context
- Population
- LOOP study participants with implantable loop recorders (ILR) and no prior atrial fibrillation (AF)758 men, median age 73 years, AF episodes ≥60 minutes detected in 96 patients (6.8%)
- Participants
- 1,411 participants
- Comparison
- Low vs higher ILR ECG-derived f-wave indices
- Outcome
- All-cause mortality
Methodological detailsMultivariate Cox regression
- Multivariate Cox regression
Main finding
As reported in the abstract
Low atrial fibrillatory rate (AFR) (<317 fpm): HR [95% CI]
2.5
1.3–4.8
Low ExpDec (<1.25): HR [95% CI]
2.8
1.4–5.5
Low FWA (<97 μV): HR [95% CI]
2.7
1.4–5.4
Secondary outcomes
Composite of cardiovascular death (CVD) or heart failure hospitalization (secondary end point)
- Low AFR: HR [95% CI]
- 4.0 [1.6-9.9]
- Low ExpDec: HR [95% CI]
- 3.7 [1.4-10.1]
- Low FWA: HR [95% CI]
- 2.9 [0.97-8.6]
- Larger uncertainty
Correlation of FWA with left atrial volume
- Significant, yet modest, negative correlation
Original publication
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