Arrhythmias & electrophysiology
Cannabis use and atrial arrhythmias: A systematic review and meta-analysis of large populational studies
Pooled result · Atrial arrhythmias (AA)Result — go to the resultRisk of AAs 71% increased risk 95% CI 1.1–2.6Authors' conclusion
Cannabis use was associated with a 71% increased risk of AAs. A significant paucity of research in non-Western and teenage populations comprise key areas for future research to better inform public health and legalization policies.
Study context
- Population
- Studies on cannabis use and atrial arrhythmias (atrial fibrillation/flutter/tachycardia, supraventricular tachycardia), participants from North America, Europe, and OceaniaFourteen observational studies, five prospective
- Participants
- 81,230,930 participants
- Comparison
- Cannabis use vs controls, pooled odds ratios for atrial arrhythmias
- Cannabis usersn = 90,195
- Controlsn = 1,487,838
- Outcome
- Atrial arrhythmias (AA)
Methodological detailsobservational studies, random-effects model, prospectively registered
- Observational studies
- Random-effects model
- Prospectively registered
Pooled result
As reported in the abstract
Risk of atrial arrhythmias (AAs)
71% increased risk
95% CI 1.1–2.6
P = 0.01
By group
- AA observed in all participants
- 1.9%
Further pooled results
Factors associated with further increased AA risk
| OR (95% CI) | P value | ||
|---|---|---|---|
| Concomitant drug useFurther increased AA risk | 1.91 (1.1–3.5) | P = 0.03 | |
| Consumption in cannabis-legal countriesFurther increased AA risk | 1.93 (1.1–3.5) | P = 0.03 | |
| 0.20.5125Odds ratio (log scale) |
Participant characteristics
- Mean age
- 47.2 years
- Female
- 63.3%
Original publication
Cannabis use and atrial arrhythmias: A systematic review and meta-analysis of large populational studies. Heart Rhythm. Published 3 June 2025. doi:10.
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