Valvular & structural heart disease
Cardiac Damage Stages and Clinical Outcomes in Patients With Severe Aortic Stenosis
Authors' conclusion
Cardiac damage staging is a useful tool for prognostic stratification in patients with severe AS, independent of gradient patterns, symptoms, and initial treatment strategies.
Study context
- Population
- Patients with severe aortic stenosis (AS), high-gradient (HG) or low-gradient (LG), from the CURRENT AS registry-2consecutive patients with severe AS · high-gradient [HG] AS 1,986 · low-gradient [LG] AS 1,383
- Participants
- 3,369 patients
- Exposure
- Adjusted HRs for stages 1, 2, and 3/4 vs stage 0
- Outcome
- All-cause death or heart failure hospitalization
Methodological detailsconsecutive patients
- Consecutive patients
Main finding
As reported in the abstract
Each group vs stage 0Hazard ratio (95% CI)
Stage 1HG AS; adjusted
2.47(1.23–4.96)
Stage 2HG AS; adjusted
3.39(1.72–6.67)
Stage 3/4HG AS; adjusted
4.01(1.95–8.25)
Stage 1LG AS; adjusted
1.72(1.04–2.84)
Stage 2LG AS; adjusted
2.28(1.44–3.61)
Stage 3/4LG AS; adjusted
2.95(1.79–4.88)
Observational data: associations, not effects.
Further findings
Primary outcome by symptoms and initial treatment strategy (subgroups)
- Higher risk with more advanced cardiac damage consistent regardless of symptoms and initial treatment strategies in both HG and LG AS
Original publication
Cardiac Damage Stages and Clinical Outcomes in Patients With Severe Aortic Stenosis. JACC Adv. Published 27 August 2025. doi:10.
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