Cardiac Damage Staging, Moderate Aortic Stenosis, and the Impact of Aortic Valve Replacement

doi:10.1016/j.jacadv.2025.102348

Valvular & structural heart disease

Cardiac Damage Staging, Moderate Aortic Stenosis, and the Impact of Aortic Valve Replacement

JACC AdvPublished 15 Nov 2025Retrospective cohort study

Read the original article ↗

Cite

Authors' conclusion

Cardiac damage stage is associated with an increasing risk of all-cause mortality and HF hospitalization in patients with moderate AS. The degree of damage accumulates as patients await AVR, which partially recovers post-AVR.

Study context

Population: Patients with moderate aortic stenosis (AS)
Participants: 688 patients

Exposure: Baseline cardiac damage stages 0, 1, 2 and 3 to 4
Outcome: Composite of:
All-cause death
HF hospitalization
Follow-up: Median 3.6 years

Methodological detailssingle-centre

Single-centre

Main finding

As reported in the abstract

All-cause death and HF hospitalization

Stage 052interval 37–72 · per 1,000 person years

Stage 1100interval 77–129 · per 1,000 person years

Stage 294interval 77–116 · per 1,000 person years

Stages 3 to 4255interval 185–352 · per 1,000 person years

Escalating baseline stage conferred an increased risk of the composite primary endpoint: P < 0.001
Mirrored in survival analyses (all-cause death and heart failure (HF) hospitalization): Plog-rank < 0.001

Observational data: associations, not effects.

Secondary outcomes

Baseline cardiac damage stage distribution

Stage 025.1%

Stage 124.1%

Stage 241.6%

Stages 3 to 49.2%

Cardiac damage stage before and after AVR

Awaiting AVR (median time 3.1 years): accumulation of cardiac damage, partially resolved at 1-year

Original publication

Cardiac Damage Staging, Moderate Aortic Stenosis, and the Impact of Aortic Valve Replacement. JACC Adv. Published 15 November 2025. doi:10.1016/j.jacadv.2025.102348

Read the original article ↗PubMed

Summarised from the published abstract; every number is checked against it