Valvular & structural heart disease
Staging Extramitral Cardiac Damage in Mitral Annular Calcification With Mitral Valve Dysfunction
Authors' conclusion
Using the proposed extramitral cardiac damage staging system in patients with MAC and significant mitral valve dysfunction, more advanced stages are associated with higher mortality.
Study context
- Population
- Adults with mitral annular calcification (MAC) and significant mitral valve dysfunction (mitral stenosis and/or at least moderate mitral regurgitation) undergoing TTE over 1 year at Mayo Clinic
- Participants
- 953 adults
- Exposure
- Extramitral cardiac damage stages 2, 3 and 4 vs stages 0 to 1
- Stages 0 to 1n = 28reference
- Stage 2n = 499
- Stage 3n = 115
- Stage 4n = 311
- Outcome
- All-cause mortality and HF hospitalization
- Follow-up
- 3.8-year follow-up
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
All-cause mortality
- Mortality significantly higher in stages 2 to 4 vs stages 0 to 1 and increased with each stage
- Survival differences maintained after adjustment for age, DM and glomerular filtration rate
Observational data: associations, not effects.
Further findings
HF hospitalization
- Significantly higher in stages 3 and 4 vs stages 0 to 1
Subgroups: moderate or severe MAC, predominant mitral stenosis, predominant mitral regurgitation
- Similar results observed
Original publication
Staging Extramitral Cardiac Damage in Mitral Annular Calcification With Mitral Valve Dysfunction. JACC Cardiovasc Interv. Published 8 July 2024. doi:10.
Summarised from the published abstract; every number is checked against it