Heart failure & cardiomyopathies
Cardiac diagnoses and long-term outcomes in ring-like late gadolinium enhancement evaluated by cardiac magnetic resonance
Authors' conclusion
Ring-like LGE is an uncommon, non-disease-specific feature found in various morpho-functional CMP phenotypes. It is associated with frequent genetically determined aetiologies and a high burden of adverse outcomes.
Study context
- Population
- Patients undergoing LGE-CMR between 2002 and 2024 with non-ischaemic ring-like late gadolinium enhancement (LGE) in the left ventricle (LV); ischaemic and amyloid cardiomyopathies (CMPs) excludedpatients with ring-like LGE among 14,091 unique patients who underwent LGE-CMR
- Participants
- 152 patients
- Outcome
- Composite of:
- All-cause mortality
- Heart transplantation
- LV assist device implantation
- Follow-up
- Median 3 years
Methodological detailsconsecutive patients
- Consecutive patients
Main finding
As reported in the abstract
Primary endpoint occurred
17.8
Observational data: associations, not effects.
Secondary outcomes
Prevalence of ring-like LGE
- Ring-like LGE identified
- 152 patients (1.1%)
- Median number of segments
- 10
- Mostly involving the inferolateral segments
Morpho-functional phenotypes
- Most frequent phenotypes were dilated and non-dilated LV CMP
Genetic testing
- Likely pathogenic/pathogenic variants, affecting both desmosomal and non-desmosomal genes
- 59 (58.4%) patients
Inflammatory CMP
- Inflammatory CMP diagnosed
- 15.8%
Other rare aetiologies
- Genetic neuromuscular diseases and inborn errors of metabolism
Secondary endpoint: sustained ventricular tachycardia, appropriate implantable cardioverter-defibrillator therapies, or sudden cardiac death · median follow-up of 3 years
- Secondary endpoint occurred
- 17.1%
Original publication
Cardiac diagnoses and long-term outcomes in ring-like late gadolinium enhancement evaluated by cardiac magnetic resonance. Eur Heart J Cardiovasc Imaging. Published 18 February 2025. doi:10.
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