Heart failure & cardiomyopathies
Prognostic Value of Myocardial T1 Mapping for Predicting Adverse Events in Hypertrophic Cardiomyopathy
Authors' conclusion
In this study of patients with hypertrophic cardiomyopathy, we found global native T1 and global extracellular volume fraction (excluding late gadolinium enhancement) to be both independently associated with HF-related events, but not sudden cardiac death in multivariable analysis. These findings are hypothesis-generating and will require external validation in larger cohorts.
Study context
- Population
- Patients with hypertrophic cardiomyopathy who underwent 3T cardiovascular magnetic resonanceconsecutive participants with hypertrophic cardiomyopathy
- Participants
- 663 patients
- Comparison
- Global native T1 and global extracellular volume fraction (excluding late gadolinium enhancement) as predictors of heart failure (HF)-related death, HF hospitalization, and sudden cardiac death or aborted sudden cardiac death
- Outcome
- Sudden cardiac death
Methodological detailsmultivariable Cox proportional hazards regression
- Multivariable Cox proportional hazards regression
Main finding
As reported in the abstract
Hazard ratio (95% CI)P value
Global native T1 excluding late gadolinium enhancement areas
1.04(0.99–1.09)
P = 0.094Global extracellular volume fraction excluding late gadolinium enhancement
1.02(0.95–1.10)
P = 0.565Further findings
| Outcome | Estimate | P value | |
|---|---|---|---|
| HF-related deathGlobal native T1 · independently associated; multivariable · multivariable Cox models | HR 1.08 per 10 ms increase (95% CI 1.02–1.16) | P = 0.014 | |
| HF-related deathGlobal extracellular volume fraction · independently associated; multivariable · multivariable Cox models | HR 1.23 per 1% increase (95% CI 1.11–1.36) | P < 0.001 | |
| Composite end point of HF-related death or HF hospitalizationGlobal native T1 · independently associated; multivariable · multivariable Cox models | HR 1.05 per 10 ms increase (95% CI 1.01–1.09) | P = 0.009 | |
| Composite end point of HF-related death or HF hospitalizationGlobal extracellular volume fraction · independently associated; multivariable · multivariable Cox models | HR 1.10 per 1% increase (95% CI 1.04–1.16) | P < 0.001 | |
| 0.512Hazard ratio (log scale) |
Original publication
Prognostic Value of Myocardial T1 Mapping for Predicting Adverse Events in Hypertrophic Cardiomyopathy. Circ Cardiovasc Imaging. Published 17 February 2025. doi:10.
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