Cohort study
Cardiac implantable electronic devices and bloodstream infections: management and outcomes
- Retrospective cohort study
- single-centre
Authors' conclusion
Diagnostic workup of defibrillator patients with BSI admitted to a non-cardiology unit is often insufficient to characterize lead-related endocarditis.
Study context
- Population
- Consecutive implantable cardioverter defibrillator (ICD)/cardiac resynchronization therapy and defibrillator (CRT-D) patients implanted 2012–202147 bloodstream infection (BSI) episodes in 36 patients
- Participants
- 515 patients
- Exposure
- BSI vs no BSI
- BSIn = 36
Main finding
All-cause mortality · median follow-up 59 months (IQR 31-87 months)
Hazard ratio
6.7
95% CI 3.9–11.2
P < 0.001
BSI vs No BSI
HR 6.7 (95% CI 3.9–11.2); P < 0.001
As reported in the abstract
Observational data: associations, not effects.
Further findings
Management of BSI episodes
- Admitted to non-cardiology units
- 92%
- Episodes without cardiac imaging
- 25 (53%)
- Short-term antibiotics
- 85%
- Chronic antibiotic suppression therapy
- 4
- System extraction
- 3
Original publication
Cardiac implantable electronic devices and bloodstream infections: management and outcomes. Eur Heart J. Published 28 March 2024. doi:10.1093/eurheartj/ehae127
Summarised from the published abstract; every number is checked against it