Radiotherapy-induced malfunctions of cardiac implantable electronic devices: A meta-analysis
Pooled result · Device malfunction with RTResult — go to the resultOdds ratio 2.75 95% CI 1.74–4.33Authors' conclusion
Our meta-analysis suggests that ICDs are more likely to be affected by RT than PMs. These adverse events, especially reset, in patients with cancer were associated with neutron-generating RT and beam energy ≥10 MV.
Study context
- Population
- Patients with cancer and cardiac implantable electronic devices (CIEDs) (pacemakers (PMs) or implantable cardioverter-defibrillators (ICDs)) receiving radiation therapy (RT)
- Participants
- 2,454 patients · 17 retrospective observational studies
- Comparison
- ICDs vs PMs
- Outcome
- PM/ICD malfunctions associated with RT
Methodological detailsSearched PubMed, Cochrane Library, Web of Science and Embase until April 2022; 550 studies initially identified
- Searched PubMed, Cochrane Library, Web of Science and Embase until April 2022; 550 studies initially identified
Pooled result
Device malfunction with RT
Odds ratio
2.75
95% CI 1.74–4.33
ICD vs PM
OR 2.75 (95% CI 1.74–4.33)
As reported in the abstract
Further pooled results
CIED failure in ICDs, photon beam energy ≥10 MV (subgroup, 5 studies)
| Comparison | OR (95% CI) | |
|---|---|---|
| Beam energy ≥10 MV | 5.28 (2.14–13.03) | |
| 0.050.21520Odds ratio (log scale) |
CIED malfunctions with neutron-generating RT
| Comparison | OR (95% CI) | P value | |
|---|---|---|---|
| Neutron-generating RTAny malfunction | 3.97 (1.70–9.26) | ||
| Neutron-generating RTReset | 5.79 (2.37–14.12) | P = 0.0001 | |
| 0.050.21520Odds ratio (log scale) |
| Outcome | OR (95% CI) | |
|---|---|---|
| CIED failure, chest RT vs other RT sites | 1.09 (0.63–1.88) | |
| 0.512Odds ratio (log scale) |
Original publication
Radiotherapy-induced malfunctions of cardiac implantable electronic devices: A meta-analysis. Heart Rhythm. Published 25 January 2023. doi:10.
Summarised from the published abstract; every number is checked against it