Cardiac magnetic resonance-derived extracellular volume radiomics in reperfused ST-elevation myocardial infarction: long-term prognostic value and risk stratification
Authors' conclusion
RadScore derived from ECV mapping was able to predict MACE and provided incremental prognostic value beyond established risk factors. Our findings underscore the potential long-term impact of acute changes in extracellular space patterns after myocardial infarction.
Study context
- Population
- Reperfused ST-elevation myocardial infarction (STEMI) patients undergoing cardiac magnetic resonance (CMR) within 1 week of the index eventmean age 60 ± 11 years, 371 males · development cohort 347 · validation cohort 94
- Participants
- 441 patientsEvents: 81 patients (18.4%)
- Predictors
- Extracellular volume (ECV)-derived radiomics [radiomics score] from cardiac magnetic resonance
- Predicted outcome
- major adverse cardiovascular events (MACE)
Methodological detailstwo centres, development and validation cohorts divided by centres
- Two centres
- Development and validation cohorts divided by centres
Model performance
As reported in the abstract
AUC
Internal test cohort
0.865(95% CI: 0.768-0.962)
External test cohort
0.821(95% CI: 0.701-0.940)
Reclassified over clinical model
Further findings
Major adverse cardiovascular events (MACE) risk, radiomics score (RadScore) above optimal threshold (RS+)
- More than 12-fold increase in MACE risk
- P < 0.001 (95% CI 2.96-47.71)
- Adjusted for known risk factors
Incremental prognostic value beyond LVEF
- RS + provides incremental prognostic value beyond LVEF
Original publication
Cardiac magnetic resonance-derived extracellular volume radiomics in reperfused ST-elevation myocardial infarction: long-term prognostic value and risk stratification. Eur Heart J Cardiovasc Imaging. Published 8 May 2025. doi:10.
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