Heart failure & cardiomyopathies
Cardiac Magnetic Resonance Feature-Tracking Identifies Preclinical Abnormalities in Hypertrophic Cardiomyopathy Sarcomere Gene Mutation Carriers
Authors' conclusion
Cardiac magnetic resonance FT-derived parameters are consistently lower in subclinical patients with HCM, and they could emerge as a good tool for discovering the disease during a preclinical phase.
Study context
- Population
- Sarcomere gene mutation carriers without overt left ventricle (LV) hypertrophy (subclinical hypertrophic cardiomyopathy (HCM)) and healthy volunteers
- Participants
- 38 vs 42
- Comparison
- Subclinical HCM vs healthy volunteers
- Subclinical HCMn = 38
- Healthy volunteersn = 42reference
- Outcome
- CMR feature tracking (FT)-derived global LV strain
Methodological detailsmulticentre, Subclinical HCM: age 41 (22-51) years, 32% men
- Multicentre
- Subclinical HCM: age 41 (22-51) years, 32% men
Main finding
As reported in the abstract
| Group | Global radial strain | Global circumferential strain | Global longitudinal strain |
|---|---|---|---|
| Subclinical HCM | 29±7.2 | −17.3±2.6 | −16.9±2.4 |
| Healthy volunteers | 47.9±7.4 | −20.8±7.4 | −20.5±2.6 |
Global radial strain
Subclinical HCM29±7.2
Healthy volunteers47.9±7.4
Global circumferential strain
Subclinical HCM−17.3±2.6
Healthy volunteers−20.8±7.4
Global longitudinal strain
Subclinical HCM−16.9±2.4
Healthy volunteers−20.5±2.6
- Subclinical HCM vs Healthy volunteers: P < 0.0001 — global radial strain
- Subclinical HCM vs Healthy volunteers: P < 0.0001 — global circumferential strain
- Subclinical HCM vs Healthy volunteers: P < 0.0001 — global longitudinal strain
Observational data: associations, not effects.
Further findings
| Outcome | Values |
|---|---|
| Diagnostic performance of FT strain (subclinical HCM vs normal subjects) | Global radial strain (cut-off 40.43%) AUC 0.946 [95% CI, 0.93-1.00] · Sensitivity 90.48% · Specificity 94.44% · Global circumferential strain (cut-off −18.54%) AUC 0.849 [95% CI, 0.76-0.94] · Sensitivity 88.10% · Specificity 72.22% · Global longitudinal strain (cut-off −19.06%) AUC 0.843 [95% CI, 0.76-0.93] · Sensitivity 78.57% · Specificity 78.95% |
| Diagnostic performance of FT strain, subclinical HCM without other phenotypic abnormalities vs healthy volunteers (subgroup) | Global radial strain (cut-off 40.43%) AUC 0.966 [95% CI, 0.92-1.00] · Sensitivity 90.48% · Specificity 95.45% · Global circumferential strain (cut-off −18.44%) AUC 0.866 [95% CI, 0.76-0.96] · Sensitivity 92.86% · Specificity 77.27% · Global longitudinal strain (cut-off −17.32%) AUC 0.838 [95% CI, 0.73-0.94] · Sensitivity 90.48% · Specificity 65.22% |
Strain differences in 23 individuals free of all ECG and CMR abnormalities (subgroup)
- Significant differences persisted
Original publication
Cardiac Magnetic Resonance Feature-Tracking Identifies Preclinical Abnormalities in Hypertrophic Cardiomyopathy Sarcomere Gene Mutation Carriers. Circ Cardiovasc Imaging. Published 2 April 2024. doi:10.
Summarised from the published abstract; every number is checked against it