Heart failure & cardiomyopathies
Systolic anterior motion of the anterior mitral valve leaflet begins in subclinical hypertrophic cardiomyopathy
Authors' conclusion
Dyskinesia of the aorto-mitral apparatus, including SAM of the elongated AMVL, is detectable in subclinical HCM before the development of LVH or left atrial enlargement.
Study context
- Population
- Sarcomere gene mutation carriers with subclinical or overt hypertrophic cardiomyopathy (HCM), and matched healthy volunteers
- Participants
- 36 / 31 / 53
- Exposure
- G+LVH- and G+LVH+ vs healthy controls
- G+LVH-n = 36
- G+LVH+n = 31
- Controlsn = 53reference
- Outcome
- Dynamic excursion of the aorto-mitral apparatus (CMR cine)
Methodological detailsCMR 1.5 Tesla, age-, sex-, and BSA-matched healthy volunteers
- CMR 1.5 Tesla
- Age-, sex-, and BSA-matched healthy volunteers
Main finding
As reported in the abstract
- G+LVH- vs controls: subtle but significant systolic anterior motion (SAM) of the anterior mitral valve leaflet (AMVL)
- P < 0.0001
- G+LVH- vs controls: reduced longitudinal excursion of ROIAAO
- P = 0.014
- G+LVH- vs controls: reduced longitudinal excursion of ROIPMVL
- P = 0.048
- Overt and subclinical HCM: excursion of ROITRIG/AMVL/PMVL positively associated with LV fibrosis burden
- P < 0.028
- G+LVH+: SAM with reduced longitudinal excursion of ROITRIG
- P = 0.049
- G+LVH+: reduced longitudinal excursion of ROIAAO
- P = 0.008
Observational data: associations, not effects.
Original publication
Systolic anterior motion of the anterior mitral valve leaflet begins in subclinical hypertrophic cardiomyopathy. Eur Heart J Cardiovasc Imaging. Published 31 July 2023. doi:10.
Summarised from the published abstract; every number is checked against it