Cardiac magnetic resonance in giant cell myocarditis: a matched comparison with cardiac sarcoidosis
Authors' conclusion
In GCM, CMR findings are qualitatively indistinguishable from CS despite myocardial inflammation being clinically more acute and injurious. When matched for LV dysfunction and presenting features, LV size and LGE mass are smaller in GCM.
Study context
- Population
- Patients with giant cell myocarditis and matched cardiac sarcoidosis controls undergoing CMRmatched controls
- Participants
- 18 vs 18
- Comparison
- Giant cell myocarditis (GCM) vs cardiac sarcoidosis (CS) on CMR
- GCMn = 18
- CSn = 18reference
- Outcome
- CMR findings of GCM compared with CS
Methodological detailsmatched for age, sex, LVEF and presenting cardiac manifestations, blinded analysts, Analysts blinded to clinical data
- Matched for age, sex, LVEF and presenting cardiac manifestations
- Blinded analysts
- Analysts blinded to clinical data
Main finding
As reported in the abstract
CMR findings: LGE mass (% of LV mass) and LV diastolic volume
GCM
17.4
mean · SD 6.3 · % of left ventricular (LV) mass
CS
25.0
mean · SD 13.4 · % of LV mass
GCM
177
± 32 · mL
CS
211
± 58 · mL
GCM vs CS: P = 0.037 · GCM vs CS: P = 0.014
- Hook sign present: GCM
- 53%
- Hook sign present: CS
- 50%
Observational data: associations, not effects.
Further findings
| Outcome | GCM | CS | P value |
|---|---|---|---|
| Presentation on admissionSymptom duration | P = 0.002 | ||
| Median symptom duration | 0.2 months | 2.4 months | |
| Troponin T >50 ng/L | 16/17 | 2/16 | |
| Median BNP propeptide | 4488 ng/L | 1223 ng/L | |
| Presentation on admissionTroponin T elevated | P < 0.001 | ||
| Presentation on admissionB-type natriuretic propeptide | P = 0.011 |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Cardiac magnetic resonance in giant cell myocarditis: a matched comparison with cardiac sarcoidosis. Eur Heart J Cardiovasc Imaging. Published 10 January 2023. doi:10.
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