Heart failure & cardiomyopathies
Cardiac magnetic resonance in heart transplant recipients: histological, clinical and cell-free DNA validation
Authors' conclusion
We provide essential T1 and T2 mapping values across cardiac segments, as well as left ventricular myocardial strain, both with and without acute rejection. These findings establish a reliable foundation for non-invasive heart transplant rejection screening.
Study context
- Population
- Paediatric and adult heart transplant recipients, 1–24 months post-transplant
- Participants
- 58 participants244 scans
- Exposure
- Cardiac magnetic resonance (CMR) T1 and T2 mapping values in heart transplant patients both with and without acute rejection
- Outcome
- Global T1 and T2 values over time
- Follow-up
- Over the 24 months post-transplant
Main finding
As reported in the abstract
T1 β
−8.9/log(month)
P < 0.001
T2 β
−0.5/log(month)
P < 0.001
Observational data: associations, not effects.
Further findings
T1 values, children · estimates at 1 month post-transplant · T1 values significantly increased during acute rejection
P < 0.001
T1 values, adults · estimates at 1 month post-transplant · T1 values significantly increased during acute rejection
P = 0.007
Association of T1 and T2 values with dd-cfDNA
- T1 positively associated with dd-cfDNA
- P < 0.001
- T2 positively associated with dd-cfDNA
- P = 0.014
Association of T2 values with left ventricular global longitudinal strain
- T2 values associated with worse left ventricular global longitudinal strain
- P < 0.001
Original publication
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