Heart failure & cardiomyopathies
Cardiac MRI-Enriched Phenomapping Classification and Differential Treatment Outcomes in Patients With Ischemic Cardiomyopathy
Authors' conclusion
CMR-enriched unsupervised phenomapping identified distinct phenogroups, which were associated with significant differential survival benefit following surgical revascularization and sMVi in patients with ICM.
Study context
- Population
- Consecutive patients with ischemic cardiomyopathy referred for cardiac magnetic resonance (CMR), 2002–2017464 primary events
- Participants
- 787 patients
- Exposure
- CMR-enriched phenogroups; surgical revascularization and surgical mitral valve intervention (sMVi) by phenogroup
- Outcome
- Death, heart transplant or LV assist device implantation
Methodological detailslatent class analysis, multivariable Cox model
- Latent class analysis
- Multivariable Cox model
Main finding
As reported in the abstract
Overall outcome by phenogroup
- 3 distinct clusters with significant differences in overall outcome
- P<0.001
Observational data: associations, not effects.
Further findings
Survival benefit of revascularization and revascularization with sMVi, by phenogroup (subgroup)
| HR (CI) | P value | ||
|---|---|---|---|
| Phenogroup 3 | 0.61 (0.43–0.88) | P = 0.0081 | |
| 0.512Hazard ratio (log scale) |
- Survival benefit of revascularization and revascularization with sMVi, by phenogroup (subgroup): most survival benefit from revascularization and revascularization with sMVi
- Survival benefit of revascularization and revascularization with sMVi, by phenogroup (subgroup): Surgical revascularization in 380 (48.3%), sMVi in 157 (19.9%)
Survival benefit of revascularization and revascularization with sMVi, by phenogroup (subgroup)
- Differential survival benefit of revascularization and revascularization with sMVi by phenogroup
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Cardiac MRI-Enriched Phenomapping Classification and Differential Treatment Outcomes in Patients With Ischemic Cardiomyopathy. Circ Cardiovasc Imaging. Published 16 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →