Heart failure & cardiomyopathies
Cardiac resynchronization therapy for patients with mild to moderately reduced ejection fraction and left bundle branch block
Authors' conclusion
CRT for patients with HFmmrEF significantly improves LVEF and ventricular remodeling after 6 months of CRT.
Study context
- Population
- Patients with LVEF 36%-50% and left bundle branch block (LBBB) (HFmmrEF) receiving cardiac resynchronization therapy (CRT)-pacemaker
- Participants
- 76 patients
- Comparison
- CRT-ON vs CRT-OFF
- Primary endpoint
- LVESV change from baseline; primary randomized comparison of 6- to 12-month changes between randomized groups
- Follow-up
- 6 and 12 months
Methodological detailsprospective, crossover at 6 months
- Prospective
- Crossover at 6 months
Primary result
As reported in the abstract
LVESV
| Group | Baseline | CRT-ON | CRT-OFF |
|---|---|---|---|
| OFF-ON | 116.1 ± 36.5 | 87.6 ± 26.0 (P < .0001) | |
| ON-OFF | 109.8 ± 23.5 | 91.7 ± 30.5 (P < .0001) | 99.3 ± 28.9 (P = .012) |
Baseline
OFF-ON116.1 ± 36.5
ON-OFF109.8 ± 23.5
CRT-ON
OFF-ON87.6 ± 26.0 (P < .0001)
ON-OFF91.7 ± 30.5 (P < .0001)
CRT-OFF
OFF-ON— not stated in the abstract
ON-OFF99.3 ± 28.9 (P = .012)
- OFF-ON: Left ventricular end-systolic volume (LVESV) reduced from baseline only after CRT-ON
- P < 0.0001
- ON-OFF: LVESV reduction effect smaller between CRT-ON and CRT-OFF
- P = 0.027
Further findings
| Outcome | P value |
|---|---|
| LVEF change from 6 to 12 months (randomized analysis)OFF-ON vs ON-OFF · significantly better change in OFF-ON | P = 0.003 |
LVEF, CRT-OFF first then CRT-ON
- LVEF at baseline
- 41.3% ±.7%
- LVEF with CRT-ON
- 46.0% ± 8.0%
- LVEF improved by CRT
- P = 0.002
LVEF, CRT-ON first then CRT-OFF
- LVEF at baseline
- 42.7% ± 4.3%
- LVEF with CRT-ON
- 48.5% ± 8.6% [P < .001]
- LVEF with CRT-OFF
- 45.9% ± 7.7% [P = .025]
Original publication
Cardiac resynchronization therapy for patients with mild to moderately reduced ejection fraction and left bundle branch block. Heart Rhythm. Published 19 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →