Cardiac structure, function, and coronary anatomy 10 years after isolated contemporary adjuvant radiotherapy in breast cancer patients with low cardiovascular baseline risk
Authors' conclusion
Aside from minor alterations of regional strains and diastolic parameters, women who received isolated RT for BC had low prevalence of coronary disease, normal global systolic function, NT-proBNP, and exercise capacity and showed no structural changes by CMR, refuting significant long-term cardiotoxicity in such low-risk patients.
Study context
- Population
- Women without prior heart disease, 11 ± 1 years after isolated radiotherapy (RT) for first left or right breast cancer (BC) (no medical oncology therapy apart from hormonal treatment)36 left, 40 right BC
- Participants
- 76 vs 54
- Exposure
- BC patients after isolated RT vs healthy controls
- BCn = 76
- Controlsn = 54reference
- Outcome
- Long-term cardiac structure and function (echocardiography, CMR, computed tomography coronary angiography (CTCA), NT-proBNP, 6MWT)
- Follow-up
- 11 ± 1 years after RT
Methodological detailsage-matched healthy controls
- Age-matched healthy controls
Main finding
As reported in the abstract
Coronary disease by CTCA (BC patients)
| Group | No or very mild coronary disease | Moderate stenosis (50-69%) | Significant stenosis (>70%) |
|---|---|---|---|
| BC | 68% | 11% | 3% |
BC
No or very mild coronary disease68%
Moderate stenosis (50-69%)11%
Significant stenosis (>70%)3%
Observational data: associations, not effects.
Further findings
| Outcome | BC | Controls | P value |
|---|---|---|---|
| CMR: late gadolinium enhancement and extracellular volume fractionExtracellular volume fraction | 28 (SD 3) | 29 (SD 3) | P = 0.15 |
CMR: late gadolinium enhancement and extracellular volume fraction
- No late gadolinium enhancement in any patient
Original publication
Cardiac structure, function, and coronary anatomy 10 years after isolated contemporary adjuvant radiotherapy in breast cancer patients with low cardiovascular baseline risk. Eur Heart J Cardiovasc Imaging. Published 21 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →