Antithrombotic Therapy in Patients With Infective Endocarditis: A Systematic Review and Meta-Analysis
Authors' conclusion
ATT in IE patients was not associated with higher frequency of cerebrovascular events or ICH. Moreover, we found that the use of anticoagulation was associated with decreased in-hospital mortality and the use of antiplatelets was associated with decreased ST.
Study context
- Population
- Patients with infective endocarditis
- Participants
- 12,151 patients12 studies
- Comparison
- Antithrombotic therapy (ATT) vs no ATT in infective endocarditis (IE)
- Outcome
- Reported in-hospital cerebrovascular events
- Follow-up
- In-hospital
Pooled result
As reported in the abstract
In-hospital cerebrovascular events
Odds ratio (95% CI)P value
Anticoagulationvs No anticoagulationn = 10,115
1.10(0.56–2.17)
P = 0.77Antiplateletvs No antiplateletn = 838
0.90(0.61–1.33)
P = 0.61Further pooled results
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| In-hospital mortalityAnticoagulationvs No anticoagulation | 0.74 (0.57–0.96) | P = 0.03 | |
| Systemic thromboembolismAntiplateletvs No antiplatelet | 0.53 (0.38–0.72) | P < 0.01 | |
| 0.20.5125Odds ratio (log scale) |
Safety
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Intracranial hemorrhageAnticoagulationvs No anticoagulation | 0.54 (0.27–1.09) | P = 0.09 | |
| Intracranial hemorrhageAntiplateletvs No antiplatelet | 0.35 (0.11–1.10) | P = 0.07 | |
| 0.10.31310Odds ratio (log scale) |
Original publication
Antithrombotic Therapy in Patients With Infective Endocarditis: A Systematic Review and Meta-Analysis. JACC Adv. Published 19 December 2023. doi:10.
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