Cardiomyopathy Prevalence and Pregnancy-Related Mortality: United States, 2010 to 2020
Authors' conclusion
Intensifying efforts to address cardiomyopathies and enhance cardiovascular health before, during, and following pregnancy may reduce the burden of maternal morbidity.
Study context
- Population
- Women aged 15 to 55 years with deliveries in the United States, 2010 to 2020 (National Inpatient Sample); pregnancy-related deaths 2015 to 2020 (Pregnancy Mortality Surveillance System)
- Exposure
- Particularly peripartum cardiomyopathy (PPCM) and OCM prevalence and adjusted prevalence ratios (aPRs) by select covariates; pregnancy-related mortality ratios (PRMR) by select covariates
- Outcome
- Overall prevalence (cases per 100,000 delivery hospitalizations)
Main finding
As reported in the abstract
Observational data: associations, not effects.
Further findings
PPCM prevalence by maternal age, neighborhood income and race
| aPR (95% CI) | ||
|---|---|---|
| Black women | 3.58 (3.36–3.82) | |
| American Indian or Alaska Native women | 1.96 (1.57–2.45) | |
| 0.20.5125Adjusted prevalence ratio (log scale) |
PPCM prevalence by chronic hypertension and diabetes
| aPR (95% CI) | ||
|---|---|---|
| Chronic hypertension | 12.17 (11.51–12.88) | |
| Diabetes | 6.25 (5.77–6.78) | |
| 0.050.21520Adjusted prevalence ratio (log scale) |
PPCM prevalence by maternal age, neighborhood income and race
- PPCM prevalence increased with advancing maternal age and decreasing neighborhood income
Pregnancy-related mortality ratio (PRMR)
- Overall cardiomyopathy PRMR
- 2.1 deaths per 100,000 live births
- PPCM PRMR
- 1.0 deaths per 100,000 live births
PRMR by age and race
- Overall cardiomyopathy PRMR, American Indian women
- 7.3 deaths per 100,000 live births
- Overall cardiomyopathy PRMR, Black women
- 6.0 deaths per 100,000 live births
- PRMR highest among those aged ≥40 years and among American Indian and Black women
Original publication
Cardiomyopathy Prevalence and Pregnancy-Related Mortality: United States, 2010 to 2020. JACC Adv. Published 25 April 2025. doi:10.
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