Rheumatoid arthritis and cardiovascular complications during delivery: a United States inpatient analysis
Authors' conclusion
Pregnant persons with RA had higher risk of preeclampsia, peripartum cardiomyopathy, arrhythmias, acute kidney injury, and venous thromboembolism during delivery hospitalizations. Furthermore, cardiometabolic risk factors among pregnant individuals with RA rose over this 15-year period.
Study context
- Population
- Delivery hospitalizations, US National Inpatient Sample, 2004–2019
- Participants
- 12,789,722 delivery hospitalizations
- Exposure
- Rheumatoid arthritis (RA) vs no RA
- RAn = 11,979
- Outcome
- Acute CV complications during delivery admissions
Methodological detailsNational Inpatient Sample, US National Inpatient Sample 2004-2019, ICD-9/ICD-10 codes
- National Inpatient Sample
- US National Inpatient Sample 2004-2019
- ICD-9/ICD-10 codes
Main finding
As reported in the abstract
Peripartum CV complications
RA vs No RAAdjusted odds ratio (95% CI)
Preeclampsia
1.37(1.27–1.47)
Peripartum cardiomyopathy
2.10(1.11–3.99)
Arrhythmias
2.00(1.68–2.38)
Observational data: associations, not effects.
Further findings
Age
P < 0.01
AKI and VTE
- Risk of AKI and VTE higher with RA
Trends 2004-2019 among RA
- Increasing trend of obesity, gestational DM and acute cardiovascular (CV) complications
Resource utilization
- Length of stay and cost of hospitalization higher with RA
Original publication
Rheumatoid arthritis and cardiovascular complications during delivery: a United States inpatient analysis. Eur Heart J. Published 1 March 2024. doi:10.
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