Cardioprotective Role of Coronary Collaterals in the Development of Intramyocardial Hemorrhage in ST-Segment Elevation MI Patients
Authors' conclusion
Extent of coronary collaterals is a determinant of IMH in revascularized STEMI.
Study context
- Population
- STEMI patients reperfused via primary percutaneous coronary intervention (PCI)124 with intramyocardial hemorrhage (IMH)
- Participants
- 294 patients
- Exposure
- No coronary collaterals vs collaterals
- Outcome
- IMH on CMR (T2∗)
- Follow-up
- 3 days post-PCI
Methodological detailsconsecutive patients
- Consecutive patients
Main finding
As reported in the abstract
IMH extent (% LV) by Rentrop collateral grade
- IMH across collateral grades
- P < 0.001
- Adjusted risk of IMH, patients without vs with collaterals: OR 5.71 (95% CI 3.16-10.33)
- P < 0.0001
Observational data: associations, not effects.
Further findings
Area at risk (% LV) · post-PCI
Mean
| Outcome | CL- | CL+ |
|---|---|---|
| MI size | 38.66% (SD 14.63%) | 19.84% (SD 13.72%) |
| Microvascular obstruction | 8.07% (SD 6.60%) | 2.17% (SD 2.35%) |
- Area at risk (% LV): P < 0.001
- MI size: P < 0.001
- Microvascular obstruction: P < 0.001
Original publication
Cardioprotective Role of Coronary Collaterals in the Development of Intramyocardial Hemorrhage in ST-Segment Elevation MI Patients. JACC Adv. Published 25 September 2025. doi:10.
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