Arrhythmias & electrophysiology
Cardiopulmonary capacity is reduced in children with ventricular arrhythmia
Authors' conclusion
Patients with PVCs have lower aerobic capacity than their healthy peers. Further worsening of exercise capacity is present when PVCs are preserved during effort.
Study context
- Population
- Children/adolescents with premature ventricular contractions (PVCs) and normal LV function
- Participants
- 49 vs 36
- Comparison
- Children with PVCs vs healthy controls
- Patientsn = 49
- Controlsn = 36reference
- Outcome
- Exercise capacity on cardiopulmonary exercise test (CPET) (VO2max, %VO2)
Main finding
As reported in the abstract
| Group | Value | %VO2 |
|---|---|---|
| Patients | mean 32.9 (SD 6.3) mL/min/kg | 71.0 ± 13.7 |
| Controls | mean 40.4 (SD 6.7) mL/min/kg | 79.3 ± 12.2 |
Value
Patientsmean 32.9 (SD 6.3) mL/min/kg
Controlsmean 40.4 (SD 6.7) mL/min/kg
%VO2
Patients71.0 ± 13.7
Controls79.3 ± 12.2
- Patients vs Controls: P < 0.01 — VO2max
- Patients vs Controls: P < 0.01 — %VO2
Observational data: associations, not effects.
Further findings
- Arrhythmia subsiding during exercise — Patients
- 76%
Exercise HR at which PVCs subsided vs VO2max
- Correlation r = 0.3
- P = 0.07
Persisting vs subsiding arrhythmia during exercise
- Worse VO2max with persisting arrhythmia
- P < 0.01
- Worse %VO2 with persisting arrhythmia
- P < 0.01
QRS and coupling interval (CInt) parameters vs VO2max
- No correlation observed
Original publication
Cardiopulmonary capacity is reduced in children with ventricular arrhythmia. Heart Rhythm. Published 22 December 2022. doi:10.
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