Arrhythmias & electrophysiology

Increased risk of incident atrial fibrillation in young adults with mental disorders: A nationwide population-based study

Heart RhythmPublished Population-based cohort study

Main findingResult — go to the resultAdjusted hazard ratio 1.526 95% CI 1.436–1.621

Authors' conclusion

Young adults diagnosed with mental disorders have a higher risk of incident AF.

Study context

Population
Adults aged 20–39 years without history of atrial fibrillation (AF), Korean National Health Insurance Database, 2009–201210% with mental disorders
Participants
6,576,582 adults
Exposure
Mental disorders vs no mental disorders
Outcome
New-onset AF during follow-up
Methodological detailsnationwide
  • Nationwide

Main finding

As reported in the abstract

Adjusted hazard ratio

1.526

95% CI 1.436–1.621

By group

Mental disorders

25.4 per 100,000 person-years

No mental disorders

17.7 per 100,000 person-years

Mental disordersvs No mental disorders
adjusted HR 1.526 (95% CI 1.436–1.621)
Incident AF events, total
8932

Observational data: associations, not effects.

Further findings

AF risk by type of mental disorder

Bipolar disorder or schizophrenia vs no mental disorders: 2-fold higher risk of AF
Depression, insomnia, anxiety disorder vs no mental disorders: 1.5- to 1.7-fold higher risk of AF

Original publication

Increased risk of incident atrial fibrillation in young adults with mental disorders: A nationwide population-based study. Heart Rhythm. Published 20 December 2022. doi:10.1016/j.hrthm.2022.12.019

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