Heart failure & cardiomyopathies
Effect of Dapagliflozin on Total Heart Failure Events in Patients With Heart Failure With Mildly Reduced or Preserved Ejection Fraction: A Prespecified Analysis of the DELIVER Trial
Primary result · Total HF events and CV deathResult — go to the resultRate ratio 0.77 95% CI 0.67–0.89Authors' conclusion
In the DELIVER trial, dapagliflozin reduced the rate of total HF events (first and subsequent HF hospitalizations and urgent HF visits) and cardiovascular death regardless of patient characteristics, including EF.
Study context
- Population
- Patients with heart failure (HF) with mildly reduced or preserved ejection fraction (EF)
- Participants
- 6,263 patients
- Comparison
- Dapagliflozin vs placebo
- Primary endpoint
- Total episodes of worsening HF (HF hospitalisation or urgent HF visit requiring IV HF therapies) and CV death
Methodological detailsprespecified analysis
- Prespecified analysis
Primary result
Total HF events and CV death
Rate ratio
0.77
95% CI 0.67–0.89
P < 0.001
Events by treatment group
Placebo
1057
events
Dapagliflozin
815
events
Dapagliflozinvs Placebo
rate ratio 0.77 (95% CI 0.67–0.89); P < 0.001
As reported in the abstract
Further findings
| Outcome | Estimate | P value | |
|---|---|---|---|
| Time to first HF event or CV deathTraditional time to first event analysis | HR 0.82 (95% CI 0.73–0.92) | P < 0.001 | |
| Total HF events (joint frailty model) | rate ratio 0.72 (95% CI 0.65–0.81) | P < 0.001 | |
| CV death (joint frailty model) | rate ratio 0.87 (95% CI 0.72–1.05) | P = 0.14 | |
| 0.512Ratio (log scale) |
Total HF hospitalisations and CV death; subgroups including EF
- Results similar for total HF hospitalisations (without urgent HF visits) and CV death and in all subgroups, including EF
Original publication
Effect of Dapagliflozin on Total Heart Failure Events in Patients With Heart Failure With Mildly Reduced or Preserved Ejection Fraction: A Prespecified Analysis of the DELIVER Trial. JAMA Cardiol. Published 1 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →