Cardiorespiratory Fitness, Coronary Artery Calcium, and Cardiovascular Disease Events in a Cohort of Generally Healthy Middle-Age Men: Results From the Cooper Center Longitudinal Study
Main finding · CVD events per additional MET of fitness, adjusted for CAC levelResult — go to the resultHazard ratio 0.89 95% CI 0.84–0.94Authors' conclusion
In a large cohort of generally healthy men, there is an attenuation of CVD risk at all CAC levels with higher CRF.
Study context
- Population
- Men without clinical cardiovascular disease (CVD) undergoing preventive medicine examinations with objective cardiorespiratory fitness (CRF) and coronary artery calcification (CAC) measurement, 1998–2007383 CVD events
- Participants
- 8,425 men
- Exposure
- Higher vs lower CRF across CAC levels
- Outcome
- CVD events
- Follow-up
- Average 8.4 years
Main finding
As reported in the abstract
CVD events per additional MET of fitness, adjusted for CAC level
Hazard ratio
0.89
95% CI 0.84–0.94
Each additional MET of fitness
HR 0.89 (95% CI 0.84–0.94)
Each additional MET of fitness, as printed
Observational data: associations, not effects.
Original publication
Cardiorespiratory Fitness, Coronary Artery Calcium, and Cardiovascular Disease Events in a Cohort of Generally Healthy Middle-Age Men: Results From the Cooper Center Longitudinal Study. Circulation. Published 17 January 2018. doi:10.
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