Cardiorespiratory Fitness, Multimorbidity Risk, and 15-Year Trajectories in Chronic Disease Accumulation: A Prospective Longitudinal Study
Main finding · MultimorbidityResult — go to the resultHazard ratio 0.79 95% CI 0.76–0.83Authors' conclusion
High CRF is associated with lower multimorbidity risk, delayed onset of multimorbidity, and significantly slower accumulation of chronic diseases.
Study context
- Population
- UK Biobank adults with cardiorespiratory fitness (CRF) estimated by 6-minute submaximal exercise test, followed up to 15 years
- Participants
- 38,348 adults
- Exposure
- High vs moderate vs low cardiorespiratory fitness
- Outcome
- Multimorbidity (≥2 of 59 common chronic diseases)
- Follow-up
- Median 11.57 years
Methodological detailsUK Biobank
- UK Biobank
Main finding
Multimorbidity
Hazard ratio
0.79
95% CI 0.76–0.83
High CRFvs Low CRF
HR 0.79 (95% CI 0.76–0.83)
As reported in the abstract
- Participants developing multimorbidity (overall)
- 15,368 (40.08%)
Observational data: associations, not effects.
Further findings
| Outcome | Difference (years) (95% CI) | |
|---|---|---|
| Median time to multimorbidity onsetHigh CRFvs Low CRFLater onset with high CRF | 1.27 (1.01–1.54) | |
| −1012Difference, years (linear scale) |
| Outcome | β (CI) |
|---|---|
| Annual rate of chronic disease accumulationHigh CRF vs Low CRF · significantly slower accumulation | −0.043 (−0.050 to −0.036) |
Original publication
Cardiorespiratory Fitness, Multimorbidity Risk, and 15-Year Trajectories in Chronic Disease Accumulation: A Prospective Longitudinal Study. JACC Adv. Published 8 October 2025. doi:10.
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