Plant-Based Diet Quality, Healthy Lifestyle, and Dementia Risk in Older Adults With Cardiometabolic Diseases
Authors' conclusion
Dementia incidence among adults with CMDs differed substantially according to plant-based diet quality. Additional healthy lifestyle behaviors were associated with significant mitigation of dementia risk only in the presence of low hPDI.
Study context
- Population
- Dementia-free UK Biobank participants aged ≥55 years with ≥2 24-hour dietary recalls9,656 (13.5%) with ≥1 CMD
- Participants
- 71,648 participants
- Exposure
- Cardiometabolic diseases (CMDs) and plant-based diet quality/lifestyle vs none
- Outcome
- Incident dementia
- Follow-up
- Median 12.5 years
Main finding
As reported in the abstract
Hazard ratio (95% CI)
CMDsvs No CMDsbaseline CMDs
1.90(1.53–2.35)
CMDs + high hPDIdementia risk associated with CMDs among those with high hPDI
0.39(0.20–0.74)
CMDs + high uPDIdementia risk associated with CMDs among those with high uPDI
3.24(1.64–6.40)
CMDs + low hPDI + other healthy lifestyle behaviorsrisk among participants with CMDs and low hPDI, attenuated in the presence of other healthy lifestyle behaviors
1.47(0.34–6.36)
- Participants who developed dementia
- 825 (1.2%)
Observational data: associations, not effects.
Original publication
Plant-Based Diet Quality, Healthy Lifestyle, and Dementia Risk in Older Adults With Cardiometabolic Diseases. JACC Adv. Published 8 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →