Cardiovascular benefit of statin use against air pollutant exposure in older adults
Authors' conclusion
Among adults aged 60 years and older with high and low or moderate levels of exposure to PM10 and PM2.5, statin use was associated with a significantly lower risk of stroke.
Study context
- Population
- Adults aged ≥60 years free of cardiovascular disease (CVD) in major metropolitan areas of the Republic of Korea, with PM10 and PM2.5 exposure in 2015
- Participants
- 1,229,444 adults
- Exposure
- Statin use vs no statin use across air pollutant exposure levels
- Statin usersn = 377,076
- Outcome
- Incident stroke
- Follow-up
- 1 January 2016 to 31 December 2021
Methodological detailspopulation-based
- Population-based
Main finding
As reported in the abstract
Incident stroke, high exposure (PM10 >50 µg/m³; PM2.5 >25 µg/m³)
Statin users vs Statin non-usersAdjusted hazard ratio (95% CI)
High PM10
0.80(0.75–0.85)
High PM2.5
0.80(0.80–0.86)
- Incident stroke events overall
- 86 018
- Stroke rate overall
- 719.0 events per 100 000 person-years (PYs)
Observational data: associations, not effects.
Further findings
Incident CVD, low or moderate exposure (PM10 ≤50 µg/m³; PM2.5 ≤25 µg/m³)
- Similar risk reduction among statin users
Original publication
Cardiovascular benefit of statin use against air pollutant exposure in older adults. Eur J Prev Cardiol. Published 14 February 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →