Cardiovascular Disease Incidence and Risk Factor Contributions in Adults Aged 45 to 59 Years With Low 10-Year and High 30-Year Risk: Findings From REGARDS
Authors' conclusion
Using Predicting Risk of CVD Events 30-year predicted total CVD risk identified a subgroup of younger adults with low 10-year and high 30-year risk who may benefit from earlier preventive interventions. Hypertension was the leading contributor to CVD in this risk category.
Study context
- Population
- Participants aged 45 to 59 years without prevalent total Cardiovascular Disease (CVD) from the REGARDS study
- Participants
- 6,761 participants
- Exposure
- Low 10-year/high 30-year risk group compared with those with low 10-year/low 30-year risk
- Outcome
- Cumulative incidence of total CVD, women
- Follow-up
- 10 years
Methodological detailssex-stratified
- Sex-stratified
Main finding
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Low 10-year/low 30-year predicted risk | Low 10-year/high 30-year predicted risk |
|---|---|---|
| Cumulative incidence of total CVD, men · 10 years | 1.5% | 6.0% |
Population attributable risk of hypertension for CVD events, low 10-year/high 30-year predicted risk group
- Women
- 57.8% (95% CI, 45.1%-70.0%)
- Men
- 28.9% (95% CI, 14.8%-43.2%)
- Hypertension was the leading contributor
Participants categorized as low 10-year/high 30-year risk
- Share of participants
- 41.9%
- Mean age [SD]
- 55.2 [3.4] years
- Female
- 52.8%
Original publication
Cardiovascular Disease Incidence and Risk Factor Contributions in Adults Aged 45 to 59 Years With Low 10-Year and High 30-Year Risk: Findings From REGARDS. Circ Popul Health Outcomes. Published 10 September 2026. doi:10.
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