Prevention & lipidsCohort study
Cardiovascular diseases and risk of dementia in the general population
- Prospective cohort study with genetic (Mendelian randomisation-type) analyses
- three prospective cohorts
- meta-analysis of cohort estimates
- time-dependent Cox regression
Authors' conclusion
Associations between stroke and all-cause dementia and its major subtypes are likely to be causal. Moreover, genetic susceptibility for ischemic heart disease is associated with incident vascular dementia.
Study context
- Population
- General population in Copenhagen City Heart Study, Copenhagen General Population Study and UK Biobank3 cohorts
- Exposure
- Cardiovascular diseases (CVDs) vs none
- Outcome
- All-cause dementia, Alzheimer's disease and vascular dementia
Main finding
As reported in the abstract
All-cause dementia, Alzheimer's disease, vascular dementia
Odds ratio (CI)
Genetic susceptibility for ischemic strokeall-cause dementia, UK Biobank
1.64(1.35–1.98)
Genetic susceptibility for ischemic strokeAlzheimer's disease, UK Biobank
1.44(1.10–1.89)
Genetic susceptibility for ischemic strokevascular dementia, UK Biobank
2.06(1.41–3.01)
Genetic susceptibility for ischemic heart diseasevascular dementia, UK Biobank
1.24(1.03–1.50)
- Observationally, CVDs associated with risk of all incident outcomes in meta-analyses; HR up to
- 7.00 (95% CI 6.20, 7.92)
Observational data: associations, not effects.
Original publication
Cardiovascular diseases and risk of dementia in the general population. Eur J Prev Cardiol. Published 6 March 2025. doi:10.1093/eurjpc/zwaf129
Summarised from the published abstract; every number is checked against it