Prevention & lipidsCohort study
Lipoprotein(a) and risk of dementia: findings from three cohort studies
- Prospective cohort study
- three cohorts
- competing risk analysis
Authors' conclusion
Low lipoprotein(a) levels were not associated with the risk of Alzheimer's disease or vascular-related dementia.
Study context
- Population
- Individuals from the Copenhagen General Population Study, the Copenhagen City Heart Study and the UK Biobank117,029 with KIV-2 data
- Participants
- 539,478 individuals
- Exposure
- Lipoprotein levels and LPA KIV-2 repeats vs risk of dementia
- Outcome
- Alzheimer's disease and vascular-related dementia
- Follow-up
- Up to 30.2 years
Main finding
As reported in the abstract
Alzheimer's disease and vascular-related dementia by lipoprotein(a) (continuous)
- Lipoprotein(a) levels on continuous scales not associated with risk of Alzheimer's disease or vascular-related dementia
Observational data: associations, not effects.
Further findings
| Outcome | subdistribution hazard ratio (95% CI) | |
|---|---|---|
| Alzheimer's disease by LPA KIV-2 number of repeats (Copenhagen studies) | 1.25 (1.06–1.46) | |
| 0.512Subdistribution hazard ratio (log scale) |
Absolute risk of vascular-related dementia with higher Lp(a), accounting for competing risk of death
- UK Biobank (n = 452 989; events = 5132): risk increased with higher Lp(a)
- P = 0.01
- Copenhagen studies (n = 80 313; events = 2734): no increase
- P = 0.42
Original publication
Lipoprotein(a) and risk of dementia: findings from three cohort studies. Eur Heart J. Published 18 August 2025. doi:10.1093/eurheartj/ehaf465
Summarised from the published abstract; every number is checked against it