Cardio-oncology & otherCohort study
Cardiovascular events following coronavirus disease 2019 vaccination in adults: a nationwide Swedish study
- Nationwide register-based cohort study
Authors' conclusion
Risk of myopericarditis (mRNA vaccines only), extrasystoles, and transient ischaemic attack was transiently increased after COVID-19 vaccination, but full vaccination substantially reduced the risk of several more severe COVID-19-associated cardiovascular outcomes, underscoring the protective benefits of complete vaccination.
Study context
- Population
- All Swedish adults
- Participants
- 8,070,674 adults
- Exposure
- Post-COVID-19 vaccination vs unvaccinated
- Outcome
- Myocarditis/pericarditis, dysrhythmias, HF, MI, and cerebrovascular events (TIA and stroke)
- Follow-up
- Several risk windows after each vaccine dose
Main finding
As reported in the abstract
CV events (myocarditis/pericarditis, dysrhythmias, HF, MI, TIA, stroke) after vaccination vs unvaccinated
Decreased risks of CV events post-vaccination for most outcomes, especially after dose three (HR range, dose three)
.69 to .81
Observational data: associations, not effects.
Safety
Myocarditis and pericarditis · 1-2 weeks after COVID-19 mRNA vaccination
- Increased risk after mRNA vaccination (replicated)
Extrasystoles
- Dose one vs unvaccinated, HR
- 1.17 (95% CI 1.06-1.28)
- Dose two vs unvaccinated, HR
- 1.22 (95% CI 1.10-1.36)
- Not increased for arrhythmias
- similar across vaccines
- stronger in elderly and males
TIA
- Vaccinated vs unvaccinated, HR
- 1.13 (95% CI 1.05-1.23)
- Not increased for stroke
- mainly in elderly
Original publication
Cardiovascular events following coronavirus disease 2019 vaccination in adults: a nationwide Swedish study. Eur Heart J. Published 30 September 2024. doi:10.1093/eurheartj/ehae639
Summarised from the published abstract; every number is checked against it