Incidence and Progression of Diastolic Dysfunction in People With HIV in Tanzania: A Comparative Cohort
Authors' conclusion
The incidence of diastolic dysfunction was similar in PLWH and HIV-uninfected controls.
Study context
- Population
- People living with HIV (PLWH) and HIV-uninfected community controls in Tanzania with echocardiogram at enrollment and follow-up367 PLWH
- Participants
- 781 participants
- Exposure
- PLWH vs HIV-uninfected controls
- PLWHn = 367
- Outcome
- Incidence of diastolic dysfunction
- Follow-up
- Up to 5 years
Methodological detailslongitudinal
- Longitudinal
Main finding
As reported in the abstract
Incident diastolic dysfunction
No difference in incidence of diastolic dysfunction by HIV serostatus
aHR 0.93 [95% CI: 0.61-1.42] (95% CI)
Observational data: associations, not effects.
Further findings
Left ventricular hypertrophy (LVH) progression after ART initiation · within 3 years of treatment
- Baseline difference in LVH before ART initiation
- 3.57 g/m² [95% CI: 0.87-6.26] (95% CI)
- No difference after 3 years; baseline differences in LVH and other diastolic dysfunction markers resolved within 3 years of treatment
Risk factors for diastolic dysfunction and LVH
- Hypertension and obesity were important modifiable risk factors for diastolic dysfunction
- both P < 0.001
- Subclinical kidney disease, anemia and manual labor predicted LVH and diastolic dysfunction
Original publication
Incidence and Progression of Diastolic Dysfunction in People With HIV in Tanzania: A Comparative Cohort. JACC Adv. Published 25 September 2024. doi:10.
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