Cardiovascular Events in US Adults Aged ≥80 Years: Incidence, Risk Factors, and Outcomes
Authors' conclusion
The risk for CVD events in adults aged ≥80 years was high, and the association was stronger for albuminuria and inflammation versus hypertension and diabetes.
Study context
- Population
- Adults aged <70, 70 to <80, and ≥80 years in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) studyparticipants by age group
- Participants
- 4,621 / 4,938 / 2,450
- Exposure
- Risk factors for the 5-year cumulative incidence of cardiovascular disease (CVD) events among adults aged <70, 70 to <80, and ≥80 years
- <70 yearsn = 4,621
- 70 to <80 yearsn = 4,938
- ≥80 yearsn = 2,450
- Outcome
- Cumulative incidence of CVD events
- Follow-up
- 5 years
Methodological detailsenrollment across the contiguous United States, adjudicated CVD events
- Enrollment across the contiguous United States
- Adjudicated CVD events
Main finding
As reported in the abstract
Observational data: associations, not effects.
Further findings
Diabetes and hypertension associated with CVD events, by age group
| HR (95% CI) | ||
|---|---|---|
| DiabetesAged <70 years | 1.42 (1.00–2.03) | |
| HypertensionAged <70 years | 1.58 (1.19–2.09) | |
| DiabetesAged 70 to <80 years | 1.41 (1.09–1.83) | |
| HypertensionAged 70 to <80 years | 1.73 (1.43–2.08) | |
| DiabetesAged ≥80 years | 1.03 (0.81–1.32) | |
| HypertensionAged ≥80 years | 1.07 (0.84–1.35) | |
| 0.512Hazard ratio (log scale) |
Risk factors for CVD events among those aged ≥80 years
| HR (95% CI) | ||
|---|---|---|
| LDL-C ≥100 mg/dL | 1.24 (1.01–1.51) | |
| hsCRP ≥3 mg/L | 1.27 (1.03–1.55) | |
| Albuminuria | 1.61 (1.30–1.98) | |
| Prior history of CVD | 2.25 (1.84–2.76) | |
| 0.20.5125Hazard ratio (log scale) |
Percent
CVD event
53.1%(95% CI 48.3%–57.8%)
Age-matched participants who did not have a CVD event
5.7%(95% CI 3.5%–7.9%)
- Age-matched
Original publication
Cardiovascular Events in US Adults Aged ≥80 Years: Incidence, Risk Factors, and Outcomes. Circ Popul Health Outcomes. Published 20 February 2026. doi:10.
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