Cardiovascular outcomes and aortic growth in pregnant women with Turner syndrome: data from the European Society of Cardiology EURObservational Research Programme Registry of Pregnancy and Cardiac Disease (ROPAC) III
Authors' conclusion
Pregnancy outcomes in women known with Turner syndrome are better than reported before. While aortic dilatation may occur during pregnancy, it appears reversible postpartum.
Study context
- Population
- Pregnancies of women known pre-pregnancy with Turner syndrome, 2018–2023
- Participants
- 47 pregnancies
- Exposure
- Moderate-to-high vs low risk of aortic events; Assisted reproductive technology (ART) vs spontaneous conception
Methodological detailsglobal
- Global
Main finding
As reported in the abstract
Maternal mortality or aortic dissection during or after pregnancy
- No maternal mortality or dissection occurred during or after pregnancy
Observational data: associations, not effects.
Further findings
| Outcome | Low risk | Moderate-to-high risk | Spontaneous | ART | P value | |
|---|---|---|---|---|---|---|
| Cesarean section | Not reported in the abstract | Not reported in the abstract | 42% | 65% | P = 0.011 | Low risk, Moderate-to-high risk: not reported in the abstract |
| Gestational age at delivery | Not reported in the abstract | Not reported in the abstract | 39 weeks | 38 weeks | P = 0.010 | Low risk, Moderate-to-high risk: not reported in the abstract |
Aortic growth · median follow-up of seven months
- Significant aortic growth at the sinus of Valsalva during pregnancy
- Aortic diameters at follow-up not different from pre-pregnancy
Safety
Hypertensive disorders
- Hypertensive disorders
- 26%
Original publication
Cardiovascular outcomes and aortic growth in pregnant women with Turner syndrome: data from the European Society of Cardiology EURObservational Research Programme Registry of Pregnancy and Cardiac Disease (ROPAC) III. Eur J Prev Cardiol. Published 8 September 2025. doi:10.
Summarised from the published abstract; every number is checked against it