Assisted Reproductive Technology for Adults With Congenital and Acquired Heart Disease
Authors' conclusion
In individuals with CVD, pregnancy outcomes following ART were comparable to those with spontaneous conception, supporting the safety of ART in this population.
Study context
- Population
- Individuals with congenital or acquired cardiovascular disease (CVD) who achieved pregnancy, followed for 1-year postpartum
- Participants
- 100 vs 200
- Exposure
- Assisted reproductive technology (ART) vs Spontaneous conception
- ARTn = 100
- Spontaneous conceptionn = 200
Methodological detailsmatched 2:1, age-matched controls
- Matched 2:1
- Age-matched controls
Main finding
As reported in the abstract
Congestive heart failure
P = 1.0
Observational data: associations, not effects.
Further findings
Sustained arrhythmia · no significant difference
P = 0.34
Hypertensive disorders of pregnancy · no difference
P = 0.20
Preterm birth · no difference
P = 0.85
Need for neonatal intensive unit admission · no difference
P = 0.13
Birthweight · no difference
P = 0.40
Short-term efficacy of ART at the primary center (exploratory)
- Subjects undergoing in vitro fertilization cycles
- 41
- In vitro fertilization cycles
- 57
- Median oocytes per retrieval
- 15
- Embryo transfers
- 85
- Implantation rate
- 56.2%
- Live birth rate
- 57.7%
- Exploratory analysis
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Assisted Reproductive Technology for Adults With Congenital and Acquired Heart Disease. JACC Adv. doi:10.
Summarised from the published abstract; every number is checked against it