Heart failure & cardiomyopathies
Catestatin as a Predictor for Cardiac Death in Heart Failure with Mildly Reduced and Preserved Ejection Fraction
Authors' conclusion
Elevated plasma catestatin might be a more sensitive predictor for cardiac outcome in patients with HFmrEF/HFpEF than in HFrEF.
Study context
- Population
- HF patients across the whole spectrum of EF
- Participants
- 228 patients
- Comparison
- Plasma catestatin as predictor of cardiac death in HFrEF vs HFmrEF/HFpEF
- Primary endpoint
- Cardiac death
- Follow-up
- Median 52.5 months
Methodological detailsprespecified subgroups
- Prespecified subgroups
Primary result
As reported in the abstract
Association of plasma catestatin with cardiac death
| Group | HR | AUC (CV death) |
|---|---|---|
| HFrEF | 1.53 (95% CI 0.99-2.37) | 0.59 (95% CI 0.587-0.849) |
| HFmrEF/HFpEF | 2.73 (95% CI 1.56-4.75) | 0.72 (95% CI 0.45-0.74) |
HR
HFrEF1.53 (95% CI 0.99-2.37)
HFmrEF/HFpEF2.73 (95% CI 1.56-4.75)
AUC (CV death)
HFrEF0.59 (95% CI 0.587-0.849)
HFmrEF/HFpEF0.72 (95% CI 0.45-0.74)
Further findings
- Similar adverse cardiac events in HFmrEF/HFpEF as in HFrEF
Original publication
Catestatin as a Predictor for Cardiac Death in Heart Failure with Mildly Reduced and Preserved Ejection Fraction. ESC Heart Fail. Published 3 October 2024. doi:10.
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