Heart failure & cardiomyopathies
Comprehensive Proteomic Profiling of Human Myocardium Reveals Signaling Pathways Dysregulated in Hypertrophic Cardiomyopathy
Authors' conclusion
Proteomic profiling and confirmatory transcriptomic profiling elucidate dysregulation of both newly recognized (eg, Ras-mitogen-activated protein kinase) and known pathways associated with pathogenesis and progression to severe forms of HCM.
Study context
- Population
- Human myocardial samples from hypertrophic cardiomyopathy (HCM) cases and nonfailing-heart controls
- Participants
- 99 vs 15
- Comparison
- HCM vs nonfailing control myocardium
- HCMn = 99
- Controlsn = 15reference
- Outcome
- Signaling pathways differentially regulated in HCM (proteomic profiling of 7,289 proteins, SomaScan; FDR <0.05), confirmed by transcriptomic profiling
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
Pathway analysis of differentially expressed proteins
- Dysregulation of Ras-MAPK, ubiquitin-mediated proteolysis, angiogenesis-related (eg, HIF-1, VEGF) and Hippo pathways
- Known HCM pathways (metabolic, inflammatory, extracellular matrix) also dysregulated
Observational data: associations, not effects.
Further findings
Proteins associated with clinical indicators of severe HCM (reduced LVEF, AF, ventricular tachyarrhythmias) and differentially expressed genes
- Pathway analyses supported the proteomic findings
Original publication
Comprehensive Proteomic Profiling of Human Myocardium Reveals Signaling Pathways Dysregulated in Hypertrophic Cardiomyopathy. J Am Coll Cardiol. Published 2 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →