Arrhythmias & electrophysiology

Catheter ablation of atrial fibrillation and atrial tachycardia in patients with pulmonary hypertension: a randomized study

EuropacePublished Randomised controlled trial

Primary resultResult — go to the resultHazard ratio 0.97 95% CI 0.49–2.0

Authors' conclusion

Extensive ablation, compared with a limited approach, was not beneficial in terms of arrhythmia recurrence in patients with AF/AT and PH.

Study context

Population
Patients with combined post- and pre-capillary or isolated pre-capillary pulmonary hypertension and supraventricular arrhythmia (atrial fibrillation (AF)/AT) indicated for catheter ablation
Participants
77 patients
Comparison
Extended ablation vs limited ablation
Primary endpoint
Arrhythmia recurrence >30 s without antiarrhythmic drugs
Follow-up
After the 3-month blanking period; median 13 (IQR 12; 19) months
Methodological detailsmulticentre (3 centres), 1:1 randomisation, parallel-group
  • Multicentre (3 centres)
  • 1:1 randomisation
  • Parallel-group

Primary result

As reported in the abstract

Hazard ratio

0.97

95% CI 0.49–2.0

Events by treatment group

Extended ablation vs Limited ablation
HR 0.97 (95% CI 0.49–2.0)

Safety

Procedural complications and clinical follow-up events including all-cause death

No excess in the Extended ablation group

Original publication

Catheter ablation of atrial fibrillation and atrial tachycardia in patients with pulmonary hypertension: a randomized study. Europace. Published 13 May 2023. doi:10.1093/europace/euad131

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