Arrhythmias & electrophysiology
Behavior-Based Electrogram Mapping Identifies Potential Functional Substrates in Atrial Fibrillation: The KSP-AF Randomized Study
Authors' conclusion
Adding KSP-guided ablation to PVI improved acute and 24-month rhythm outcomes in this single-center trial. These findings support further evaluation of behavior-based mapping to identify potential functional AF substrates and require multicenter confirmation.
Study context
- Population
- Patients with paroxysmal or persistent atrial fibrillation (AF) undergoing first-time ablation
- Participants
- 100 patients
- Comparison
- Pulmonary vein isolation (PVI) plus KSP-guided ablation vs PVI alone
- Primary endpoint
- Single-procedure freedom from documented AF recurrence without antiarrhythmic drugs
- Follow-up
- 24 months
Primary result
As reported in the abstract
Hazard ratio
0.38
95% CI 0.18–0.79, event not clearly stated
P = 0.010
By group
PVI + KSP vs PVI alone
HR 0.38 (95% CI 0.18–0.79), event not clearly stated; P = 0.010
Further findings
Acute AF termination
P < 0.001
| Outcome | PVI + KSP | PVI alone | HR (95% CI) | P value | |
|---|---|---|---|---|---|
| Freedom from AF/atrial tachycardia recurrence · 24 months | 68% | 46% | 0.49 (0.25–0.97) | P = 0.040 | |
| 0.20.5125Hazard ratio (log scale) |
Within-recording temporal dominant frequency (DF) variability
- Coefficient of variation (low)
- 4.8 ± 1.2%
- DF analysis included 93 KSP regions from 18 patients, assessed across four consecutive 5-second epochs
Original publication
Behavior-Based Electrogram Mapping Identifies Potential Functional Substrates in Atrial Fibrillation: The KSP-AF Randomized Study. Europace. Published 2 November 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →