Heart failure & cardiomyopathies
Catheter ablation versus medical rate control for persistent atrial fibrillation in older heart failure patients with reduced ejection fraction
Primary result · Changes in left ventricular ejection fraction (LVEF)Result — go to the resultEstimate 8.7 CI 5.9–11.5Authors' conclusion
This limited small-scale randomised study showed that CA in older patients with PerAF and HFrEF was associated with a lower likelihood of unplanned hospitalisations due to worsening heart failure with improvement in LVEF and lower AF burden.
Study context
- Population
- Older patients with persistent atrial fibrillation (PerAF) and heart failure with reduced ejection fraction (HFrEF)mean age 69.5±3.9 years, randomly allocated
- Participants
- 89 patients
- Comparison
- Catheter ablation (CA) versus medical rate control
- CA groupn = 45
- Medical rate control (MRC) groupn = 44
- Primary endpoint
- Changes in left ventricular ejection fraction (LVEF)
Methodological detailslimited small-scale
- Limited small-scale
Primary result
As reported in the abstract
Estimate
8.7
CI 5.9–11.5
P < 0.001
Change by group
CA group
from baseline 36.1%±2.7% to 48.9%±7.1%
Further findings
Sinus rhythm rate · 12 months
- Worsening heart failure requiring unplanned hospitalisation · 12 months · occurred less frequently in the CA group
- P = 0.019
New York Heart Association functional class and AF burden
- Improvement compared with baseline in CA group than MR group
Baseline characteristics
- Baseline characteristics were similar between the two groups
Original publication
Catheter ablation versus medical rate control for persistent atrial fibrillation in older heart failure patients with reduced ejection fraction. Heart. Published 20 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →