Insulin resistance drives cognitive impairment in hypertensive pre-diabetic frail elders: the CENTENNIAL study
Authors' conclusion
Taken together, our data highlight for the first time the association between insulin resistance and global cognitive function in frail elders with hypertension and pre-diabetes.
Study context
- Population
- Frail, hypertensive, pre-diabetic elders (age >65 years, Montreal Cognitive Assessment (MoCA) Score <26), Avellino local health authority (ASL AV), Italy, March 2021–March 2022141 completed
- Participants
- 178 participants
- Outcome
- Association between insulin resistance (HOMA-IR) and cognitive impairment (MoCA Score)
Methodological detailsconsecutive patients, single-centre
- Consecutive patients
- Single-centre
Main finding
As reported in the abstract
Strong inverse correlation between MoCA Score and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) (r)
−0.807
Observational data: associations, not effects.
Original publication
Insulin resistance drives cognitive impairment in hypertensive pre-diabetic frail elders: the CENTENNIAL study. Eur J Prev Cardiol. Published 17 May 2023. doi:10.
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