Heart failure & cardiomyopathies
Centrally adjudicated vs. investigator-reported outcomes in randomized heart failure trials
Authors' conclusion
Positive adjudication rates were lower for heart failure events than cardiovascular death, but even negatively adjudicated heart failure events are prognostically important. Central adjudication of events did not alter the results (precision or estimated log(HR)), though some variation was observed, depending on the indication.
Study context
- Population
- CV outcome trials with >1000 patients including centrally adjudicated HF outcomes7 trials
- Comparison
- Centrally adjudicated vs investigator-reported outcomes
- Outcome
- Correlation of log(HR), centrally adjudicated vs investigator-reported events
Pooled result
As reported in the abstract
CV death: R2 (95% CrI 0.53-0.93)
.80
CV death or HF hospitalization: R2 (95% CrI 0.46-0.93)
.79
HF hospitalization: R2 (95% CrI 0.10-0.83)
.57
Further pooled results
Positive adjudication rates of investigator-reported events
- CV death (range)
- 87.9%-99.2%
- HF hospitalization (range)
- 61.6%-88.0%
Subsequent all-cause death after positively vs negatively adjudicated HF hospitalizations
- Risk similar for positively and negatively adjudicated HF hospitalizations
Original publication
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