Heart failure & cardiomyopathies
Cerebral Hypometabolism Mediates the Effect of Stroke Volume on Cognitive Impairment in Heart Failure Patients
Authors' conclusion
HF patients suffered cerebral metabolic and structural alterations in regions associated with cognition.
Study context
- Population
- Patients with heart failure (HF) caused by ischaemic heart disease and healthy volunteers
- Participants
- 42 vs 32
- Exposure
- HF patients vs healthy controls
- HFn = 42
- Normal controlsn = 32reference
- Outcome
- Cerebral hypometabolism, cognition and cardiac stroke volume
Methodological detailsage- and sex-matched controls, simultaneous positron emission tomography (PET)/magnetic resonance (MR), mediation analysis
- Age- and sex-matched controls
- Simultaneous PET/MR
- Mediation analysis
Main finding
As reported in the abstract
- HF: regional hypometabolism (bilateral calcarine, caudate, thalamus, hippocampus, precuneus, posterior cingulate, lingual and olfactory cortex) and grey matter volume (GMV) reduction in bilateral thalamus and hippocampus
- P < 0.05
- Standardized uptake value ratio (SUVR) of hypometabolic regions correlated with Montreal Cognitive Assessment (MoCA) score
- r = 0.55, P = 0.038
- SUVR of hypometabolic regions correlated with cardiac stroke volume
- r = 0.49, P = 0.002
- Mediation effect of cerebral hypometabolism on stroke volume–MoCA relationship
- 33.2%
Observational data: associations, not effects.
Original publication
Cerebral Hypometabolism Mediates the Effect of Stroke Volume on Cognitive Impairment in Heart Failure Patients. ESC Heart Fail. Published 30 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →