Valvular & structural heart disease
Changes and Prognostic Implications of Myocardial Work in Aortic Stenosis Subtypes Undergoing Transcatheter Valve Implantation
Main finding · All-cause mortality per 100 mm Hg% higher pre-TAVI GWIResult — go to the resultHazard ratio 0.96 95% CI 0.92–1.00Authors' conclusion
GWI increases in patients with reduced LVEF after TAVI across AS subtypes whereas GWI decreases in patients with preserved LVEF. Assessment of GWI offers additional prognostic implications beyond LVEF and global longitudinal strain.
Study context
- Population
- Patients with aortic stenosis (AS) undergoing transcatheter aortic valve implantation (TAVI)
- Participants
- 473 patients
- Exposure
- High gradient vs Low flow/low gradient vs Normal flow/low gradient
- Outcome
- All-cause mortality
- Follow-up
- Median 60 months (IQR: 45-69 months)
Main finding
As reported in the abstract
All-cause mortality per 100 mm Hg% higher pre-TAVI GWI · median follow-up 60 months
Hazard ratio
0.96
95% CI 0.92–1.00
P = 0.033
Each 100 mm Hg% higher pre-TAVI GWI
HR 0.96 (95% CI 0.92–1.00); P = 0.033
Each 100 mm Hg% higher pre-TAVI GWI, as printed
Observational data: associations, not effects.
Further findings
Prevalence of AS subtypes
| Outcome | High gradient | Low flow/low gradient | Normal flow/low gradient |
|---|---|---|---|
| Delta GWI, pre-TAVI to 1 month, LVEF ≥50% (subgroup) | −353 (SD 589) mm Hg% | −151 (SD 652) mm Hg% | −348 (SD 606) mm Hg% |
| P | P < 0.01 | P = 0.13 | P < 0.01 |
| Delta GWI, pre-TAVI to 1 month, LVEF <50% (subgroup) | 127 (SD 491) mm Hg% | 106 (SD 510) mm Hg% | 107 (SD 550) mm Hg% |
| P | P = 0.05 | P = 0.06 | P < 0.27 |
Original publication
Changes and Prognostic Implications of Myocardial Work in Aortic Stenosis Subtypes Undergoing Transcatheter Valve Implantation. JACC Adv. Published 31 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →